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We have 1 hotel in Depew.

Pink Fountain Motor Inn        
5474 Transit Road

Pink Fountain Motor Inn puts you just 4.2 mi (6.8 km) from the airport and within a 15-minute drive of Buffalo Museum of Science.
More on Depew .
Depew is a village in Erie County, New York, United States. The population was 15,303 at the 2010 census. It is part of the Buffalo - Niagara Falls Metropolitan Statistical Area.