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We have 3 hotels in Sancti-Spiritus.

Molino De Valeriano        
Carretera Estacion S/N

Molino De Valeriano is ideally situated in peaceful village surrounds, a short car ride from Ciudad Rodrigo and Fuentes de Onoro. It also offers luggage storage, a garden and a tour desk.The room includes a private terrace, a refrigerator and a coffee maker.
Hostal La Ponderosa        
Carretera Nacional 620 km 303

Located 43.5 miles from Salamanca and 24.9 miles from the Portugal border, Hostal La Ponderosa features air-conditioned rooms with free Wi-Fi.
Casa Rural La Cenicienta Star Rating 1        
Barcelona, 17

La Cenicienta offers rustic 3-bedroom villas in Sancti-Spíritus, 43.5 miles from Salamanca. Each has a garden with barbecue and sun terrace.
More on Sancti-Spiritus .
Sancti - Spiritus is a village and municipality in the province of Salamanca province, in the autonomous community of Castile - Leon, Spain. It is 70 km away from Salamanca, the capital of the province. It is situated 756 m above the sea level.