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We have 3 hotels in Sancti-Spiritus.

Casa Rural La Cenicienta Star Rating 1        
Barcelona, 17

La Cenicienta offers rustic 3-bedroom villas in Sancti-Spíritus, 43.5 miles from Salamanca. Each has a garden with barbecue and sun terrace.
Hostal La Ponderosa        
Carretera Nacional 620 km 303

Located 43.5 miles from Salamanca and 24.9 miles from the Portugal border, Hostal La Ponderosa features air-conditioned rooms with free Wi-Fi.
Molino De Valeriano        
Carretera Estacion S/N

Molino De Valeriano is ideally situated in peaceful village surrounds, a short car ride from Ciudad Rodrigo and Fuentes de Onoro. It also offers luggage storage, a garden and a tour desk.The room includes a private terrace, a refrigerator and a coffee maker.
More on Sancti-Spiritus .
Sancti - Spiritus is a village and municipality in the province of Salamanca province, in the autonomous community of Castile - Leon, Spain. It is 70 km away from Salamanca, the capital of the province. It is situated 756 m above the sea level.