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We have 4 hotels in Santa Cruz de la Sierra.

 
 
Casa Del Conde Santa Cruz de la Sierra        
Plaza de la Independencia, 9

This 16th-century rustic house in Santa Cruz de la Sierra's main square, is 10 minutes' drive from Trujillo. Casa del Conde features a garden patio, barbecue facilities and 2 lounges with fireplaces.You can rent rooms or the whole house.
El Casino de Santa Cruz Star Rating 3        
Plaza de España, 7

These rustic apartments are set in the village of Santa Cruz de la Sierra, 10 minutes' drive from Trujillo. El Casino de Santa Cruz is 0.6 miles from the A5 Motorway.
Casa Rural Dona Blanca        
Mario Roso de Luna,1

Featuring air conditioning, Casa Rural Doña Blanca offers pet-friendly accommodation in Santa Cruz de la Sierra. Cáceres is 29.8 miles from the property.
Apartamentos Rurales La Casa de Luis        
Francisco Pizarro, 7

Apartamentos Rurales La Casa de Luis is ideally located in peaceful village surrounds, a short drive from Trujillo and La Cumbre. Those staying at the property can also take advantage of free Wi-Fi throughout their stay.The lodgings at the vacation rental have an in-room dining area, a private bathroom and a refrigerator.
 
 
More on Santa Cruz de la Sierra .
 
Santa Cruz de la Sierra is a municipality located in the province of Cáceres and autonomous community of Extremadura, Spain. The municipality covers an area of 44.6 square kilometres and as of 2011 had a population of 278 people.