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We have 1 hotel in Seneca Knolls.

Comfort Inn Fairgrounds Star Rating 2        
7010 Interstate Island Rd

Situated at the intersection of Interstates 90 and 690, this casual hotel is 2.9 miles from Onondaga Lake County Park, 4.9 miles from New York State Fairgrounds and 10.
More on Seneca Knolls .
Seneca Knolls is a hamlet in Onondaga County, New York, United States. The population was 2,011 at the 2010 census. Seneca Knolls is in the eastern part of the town of Van Buren.