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We have 5 hotels in Seneca.

Best Western Executive Inn Seneca Star Rating 2        
511 Us Highway 123 Bypass

This unpretentious hotel off US-123 is 8.8 miles from South Carolina Botanical Garden.Low-key rooms and suites come with kitchenettes, free WiFi, TVs, coffeemakers and desks.
Hampton Inn &Suites Seneca-Clemson Area        
1011 East North 1st Street

This relaxed, modern hotel is 6.8 miles from the Clemson University campus and 8 miles from the South Carolina Botanical Garden.The contemporary rooms feature free Wi-Fi and custom-designed beds, plus flat-screen TVs, microwaves, minifridges and coffeemakers.
Days Inn Seneca Star Rating 2        
11015 N Radio Station Rd

Set in a commercial area, this down-to-earth hotel is 4 miles from Lake Keowee Marina, 9 miles from Clemson University, and 2 miles from downtown restaurants and shops.Relaxed, warmly decorated rooms offer free Wi-Fi and flat-screen TVs, as well as microwaves, minifridges, and tea and coffeemakers. Kids stay at no charge with an adult.
Quality Inn Seneca Star Rating 2        
226 Hi-Tech Road

Hotel offering modest rooms in a plantation-style building with a gym, plus free Wi-Fi & breakfast...
Executive Inn of Seneca        
299 Bypass 123

Located in Seneca, South Carolina, this motel offers a daily continental breakfast. Free Wi-Fi access is available.A microwave and refrigerator come standard in each room at Executive Inn of Seneca.
More on Seneca .
Seneca is a city in Oconee County, South Carolina, United States. The population was 8,102 at the 2010 census.