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We have 1 hotel in Adrian.

Best Western Inn Santa Rosa New Mexico Star Rating 3        
2491 Historic Route 66 P.O. Box 501

The Best Western Santa Rosa Inn, rated among the top 10 to 15 percent of over 2400 Best Westerns in North America including Canada during regular quality assurance inspections. Located on Interstate 40 right off Exit 277, we provide easy access on and off Interstate 40. We feature all 44 ground level (single story) front-door-parking rooms set up in a quiet location within sight of the 9-hole Santa Rosa Golf Course.
More on Adrian .
Adrian is a city on historic route 66 in Oldham County, Texas, United States. The population was 159 at the 2000 census. A July 1, 2008 U.S. Census Bureau estimate placed the population at 149.