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We have 7 hotels in Big Pine Key.

 
 
Parmer's Resort Star Rating 2.5        
565 Barry Avenue

This low-key waterfront resort comprising low-rise buildings is 0.5 miles from the Overseas Highway and 9 miles from marine sanctuary tours at Bahia Honda State Park.The down-to-earth rooms offer free Wi-Fi, cable TV, and balconies or patios.
Little Palm Island Resort & Spa Star Rating 5        
28500 Overseas Highway Mile Marker 28.5

Set on a private island accessed only by seaplane or boat, this luxe resort is 5 miles from the National Key Deer Refuge and 29 miles from Key West International Airport.Featuring thatched roofs, vaulted ceilings and island-inspired furnishings, the chic TV-free bungalows come with furnished private decks with ocean views, outdoor showers and separate living rooms. Some also have whirlpool tubs.
Dolphin Marina & Cottages Star Rating 2        
28530 Overseas Highway

Overlooking the ocean and the North Pine channel, this marina with cottage accommodations is 7.2 miles from Coupon Bight Aquatic Preserve and 7.4 miles from the National Key Deer Refuge.
Looe Key Reef Resort Star Rating 2        
27340 Overseas Highway

Fronting US-1 on the east side of Ramrod Key, this straightforward motel and dive center is 7 miles from Scout Key and 8 miles from National Key Deer National Wildlife Refuge.Simple rooms feature free Wi-Fi and flat-screen TVs, in addition to minifridges, microwaves and coffeemakers. Some have sitting areas with sofas.
Looe Key Villa        
27403 Antigua Road

Fronting US-1 on the east side of Ramrod Key, this straightforward motel and dive center is 7 miles from Scout Key and 8 miles from National Key Deer National Wildlife Refuge.Simple rooms feature free Wi-Fi and flat-screen TVs, in addition to minifridges, microwaves and coffeemakers. Some have sitting areas with sofas.
Sunshine Key RV Resort & Marina Star Rating 2        
38801 Overseas Highway

Sunshine Key RV Resort & Marina features a marina and puts you 2 mi (3.2 km) from Bahia Honda State Park and Beach. After having fun at the outdoor pool, you can grab a bite to eat at the restaurant.
Ed & Ellen's Lodging Big Pine Key        
1547 Narcissus Avenue

These Big Pine Key, Florida apartments feature a fully equipped kitchen and a private balcony with a view of the Intracoastal Waterway. Fishing dock access is included.The spacious apartment includes an en suite dining area and separate seating area.
 
 
More on Big Pine Key .
 
Big Pine Key is a census - designated place and unincorporated community in Monroe County, Florida, United States on an island of the same name in the Florida Keys. As of the 2000 census, the town had a total population of 5,032.