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We have 14 hotels in Santee.

Comfort Inn & Suites Santee Star Rating 3        
221 Britain Street

Set between Interstate 95, Route 15 and Highway 6, this modern hotel is 1.5 miles from Lake Marion and 0.9 miles from Lake Marion Golf Course.
Howard Johnson Santee Star Rating 2        
249 Britain Street

This informal budget hotel, set in a low-rise building, is 3 miles from Santee Cooper Country Club and 7 miles from Elloree Heritage Museum and Cultural Center.The laid-back rooms offer free Wi-Fi and cable TV, plus tea and coffeemakers, microwaves and minifridges. Kids age 17 and under stay without charge.
Americas Best Value Inn Santee Star Rating 2        
9091 Old Hwy 6

This utilitarian roadside hotel off I-95 is 2 miles from the golf courses at Santee Cooper Country Club, and 6 miles from the Santee Indian Mound and Fort Watson archaeological site.Accessed by exterior corridors, the old-school rooms feature complimentary Wi-Fi and flat-screen TVs, along with microwaves, minifridges and coffeemakers. Kids age 17 and under stay free with a family member.
BEST WESTERN Plus Santee Inn Star Rating 3        
I-95 Exit 98 P. O. Box 188

This straightforward hotel is a 3-minute walk from Lake Marion Golf Course and 2.9 miles from Lake Marion Resort and Marina.The relaxed rooms offer free WiFi and flat-screen TVs with satellite channels, plus minifridges and coffeemakers.
Hampton Inn Santee Star Rating 3        
9060 Old #6 Highway

Off Interstate 95, this classic hotel is 2 miles from Santee State Park, which borders Lake Marion, and 7 miles from Santee National Wildlife Refuge.Coffeemakers, minifridges, flat-screen TVs, and both full and lap desks (for working on the bed) are offered in rooms and suites, as well as free Wi-Fi, microwaves and custom-designed beds. Suites add whirlpool tubs.
Holiday Inn Santee Star Rating 3        
139 Bradford Blvd

Off Interstate 95, this contemporary hotel is 0.8 miles from Lake Marion Golf Course, 1.7 miles from Santee State Park and 5 miles from Lake Marion.
Econo Lodge Santee Star Rating 2        
9112 Old Number 6 Hwy

Located next to Highway 15, this relaxed hotel is 2.6 miles from Santee State Park and 1.3 miles from Interstate 95.
Quality Inn and Suites Santee (South Carolina) Star Rating 3        
8929 Bass Drive

This colonial-style hotel off I-95 is 4.7 miles from Santee State Park and access to Lake Marion, and 18.6 miles from Santee National Wildlife Refuge.
Super 8 Santee Star Rating 2        
9125 Old Hwy 6

This standard budget hotel is off Interstate 95, 1.8 miles from Santee and 1.6 miles from the shore of Lake Marion.
Rodeway Inn Santee South Carolina Star Rating 2        
9117 Old Number 6 Hwy

Off of Interstate 95, this budget hotel lies 3 km from Santee State Park and 9 km from the Santee Indian Mount and Fort Watson archaeological site.The warm, down-to-earth rooms feature flat-screen TVs, free Wi-Fi, minifridges and microwaves, as well as tea and coffeemaking facilities.Complimentary breakfast is served in an informal dining room.
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Santee is a town in Orangeburg County along the Santee River Valley in central South Carolina of the United States. It has become a resort town of note located centrally north - south along the Atlantic Seaboard of South Carolina.